For the most part, the new version sticks pretty closely to the 2002 animated film. The story centers on two sisters, Lilo and Nani, who are navigating life after the death of their parents. Nani, a teenager just about to head to college, struggles to hold down a job and watch out for her sister, who is a bit chaotic.

The live-action Lilo & Stitch remake changes a specific detail about one of the main characters from the original animated film.