The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The Bills (9-2) are looking to build on a six-game win streak, while the 49ers (5-6) have lost their last two.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6). San Francisco has been up and down all season, but the Super Bowl hangover ...

The Buffalo Bills (9-2) are moving on to their their Week 13 contest against the San Francisco 49ers (5-6). Prior to that, preparations are underway. Most weeks, the prep begins on Wednesday. Largely considered "Media Day" each week,

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.