These random molecules were fed a collection of three-base-long RNAs, each linked to a chemical tag. The idea was that if a molecule is capable of ligating one of these short RNA fragments to itself, ...

The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...

Base pairs are at the heart of molecular biology information. Recognized ever since their discovery by Watson and Crick in 1953, the base pair provides, among other things, rules for copying DNA, ...