In this interview, Pedro Machado shares expertise on electron microscopy, detailing sample preparation methods and the critical role of multimodal imaging in biological studies. Multimodal biological ...

Nucleic acid extraction from biological samples is inherently difficult to execute consistently across different tissue types. Some tissue matrices are fibrous, contained in protective cell walls, or ...

Cryo-electron microscopy (cryo-EM) single particle analysis has rapidly become a cornerstone technique for high-resolution ...

Observations at the nanoscale can provide profound insights into materials science. Yet, the characterization of beam-sensitive and reactive materials has proven challenging. In order to address this ...

Sample preparation plays a crucial role in bioanalytical analysis involving chromatography. Insufficient sample preparation, such as skipping protein precipitation, phospholipid removal (PLR), ...

Although next-generation sequencing (NGS) keeps giving—exploring the human genome and revolutionizing our knowledge of health and disease—it needs to take a little, too. At the very least, NGS ...

Sample preparation is essential when employing chromatography for bioanalytical analysis as system performance will be negatively affected if it is not performed. Preparation methods include protein ...

While flow cytometry has become a prominent technology in both research and clinical laboratories, the sample preparation workflow is often still highly manual. Variabiability in this workflow, as ...

Four principal methods govern the preparation of samples for XRF analysis, each representing a different trade-off between analytical quality and speed/cost of preparation. A method involving the ...

Manual sample prep consumes 60% of time spent during analysis and contributes to 30% of errors. Automated sample prep ...