Chaperones support protein folding in different cellular compartments and some chaperones associate with ribosomes to help fold newly synthesized proteins. Two studies by Koplin et al. and Albanèse et ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Plants rely on a sophisticated network of molecular chaperones—such as Hsp70 and Hsp40 (DnaJ) proteins and their co-chaperones—to preserve proteome integrity under environmental extremes. These ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

A recent study from CU Boulder researchers shows that cells must actively work to keep sticky molecules, known as ribonucleic acid (RNA), apart, or they may form large assemblies that could cause ...

Figure 1: The molecular chaperone network. Client proteins rely on sequential interactions with chaperones, cochaperones, and chaperonins to fold into an active, native, state. Thus, functional levels ...

Like a parent of teenagers at a party, Mother Nature depends on chaperones to keep one of her charges, the immune system, in line so that it doesn't mistakenly attack normal cells, tissues and organs ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

A team of researchers from the College of Natural Sciences is the first to show how proteins called “chaperones” are vital in ensuring that neurons can transmit signals to one another. When this ...