DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important defense systems is homologous recombination, a high-precision repair pathway ...

A new study suggests the APOE2 longevity gene may protect the brain from Alzheimer's by helping neurons repair DNA damage and ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

Learn more about a new experimental procedure that uses cancer cells’ DNA repair system against itself to make drug-resistant tumors treatable again. Cancer’s ability to adapt is one of its most ...

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

Researchers have identified a pathway that triggers an immune response in cells with defective DNA repair. In particular, the authors of a new paper demonstrated how the downregulation of AUF1 impairs ...

The study focused on rare DNA damage-repair (DDR) disorders, including Ataxia-Telangiectasia (A-T) and Bloom syndrome. These conditions disrupt the body’s ability to repair routine DNA damage, causing ...

Chemotherapy drugs are designed to shatter tumor DNA so thoroughly that cancer cells cannot survive. But one of the most ...