In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

Understanding gene regulation may be key to interpreting human disease genetics. Genes are regulated in part by stretches of ...

For decades, the hunt for the genetic roots of common disease has focused overwhelmingly on single-letter changes in the DNA ...

The newest DNA sequencing technology from Swiss multinational Roche doesn’t measure DNA directly but in fact analyzes a different polymer altogether. The technology is not yet available for sale, but ...

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome. Transposons play critical roles in immune response, ...

Scientists have found unusual four-stranded DNA shapes in human blood plasma. These G-quadruplex structures suggest hidden ...

Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers that ...

Scheme showing the structure of cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine. Adding a methyl group to the DNA base cytosine represses gene expression in mammalian cells. To remove the ...

Schizophrenia, height, cholesterol. Each has its own genetic signature. That signature is made up of genetic variants: small ...

Scientists have discovered that platinum-based chemotherapy drugs commonly used to treat childhood cancers can cause ...