The researchers established a cellular imaging technique that read out the activity of the HSF1 pathway in cancer cells. This enabled them to screen a library of chemical compounds to discover a ...

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.

A pharmaceutical company initiated a phase 1b study in patients with platinum-resistant, ARID1a-mutated ovarian carcinoma. Nuvectis Pharma announced that it has initiated a phase 1b study to assess a ...

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.

Add Yahoo as a preferred source to see more of our stories on Google. An innovative new drug being trialled to tackle certain cancers could also benefit patients with advanced prostate cancer whose ...

For the first time, researchers have discovered a link between a pathway that activates a protein called heat shock transcription factor 1 (HSF1) and leukemia. Blocking even just a single gene in this ...

Scientists at Duke University School of Medicine in Durham, North Carolina, have developed a small-molecule inhibitor of the cellular stress-protective transcription factor, heat shock factor 1 (HSF1) ...

Hypertension-induced cardiac hypertrophy and apoptosis are major characteristics of early-stage heart failure. Our previous studies found that the activation of insulin-like growth factor receptor II ...

Scientists pinpoint an unusual culprit in cancer: a family of genes that respond to temperature changes in the body. Disruptions in circadian rhythm -- the ways that our bodies change in response to ...