University of Wisconsin researchers Sushmita Roy and Erika Da-Inn Lee have developed a new computational tool that maps changes in the genome, ultimately helping researchers see DNA’s 3D organization ...

Two new studies show how a seeming tangle of DNA is actually organized into a structure that coordinates thousands of genes ...

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 ...

This image depicts the detection of structural variants (SVs) at low sequencing coverage in both unique and repetitive regions by genomic proximity mapping (GPM), compared with other SV-calling ...

MIT researchers discovered that the genome’s 3D structure doesn’t vanish during cell division as previously thought. Instead, tiny loops called microcompartments remain (and even strengthen) while ...

Chromosome compartment analysis of a cancer cell line cohort reveals different subsets of compartment changes where some track epithelial to mesenchymal transition while others reflect secondary ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...