Liver disease is a major global health problem, causing over two million deaths worldwide each year. While animal models have ...

(A) Distinct phases of APAP-ALF. (B) Integrative multimodal approaches, including single-nucleus RNA sequencing spatial transcriptomics, four-dimensional intravital imaging and lineage tracing in both ...

The liver is the only internal organ that can regenerate itself. Remarkably, even if 70 percent of the liver is removed, its tissue can regrow into a full-sized organ within a matter of months. By ...

New data highlight liver-encoded delivery of immune modulators as a strategy to mitigate age-related immune dysfunction.

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice - dubbed ...

Differentiated hepatocyte organoids formed networks of small canals that allowed bile acid to pass, in a manner similar to human tissue. While organoids aim to mimic human organs, the liver’s ...

The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.

Excessive fructose intake from soft drinks is linked to liver damage and NAFLD. Lifestyle modifications are essential for ...

Medically reviewed by Robert Burakoff, MD Key Takeaways The liver can recover from metabolic-associated steatohepatitis (MASH) if drinking stops and a healthier diet is adopted.Chronic alcohol use can ...