Northwestern Medicine scientists in the laboratory of Stephen Miller, Ph.D., professor emeritus of Microbiology–Immunology, have identified the cellular and molecular mechanisms required for the ...

The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

The immune system is the frontline protection against infection, continually searching for and destroying unknown pathogens. While typical operation of the immune system scans for threats, some ...

The immune system is responsible for safeguarding the body from external and internal dangers. It does this, for the most part, by targeting and eliminating perceived threats ranging from invading ...

Autoimmune diseases stem from a complicated interplay of immune dysregulation, characterized by chronic inflammation and the loss of self-tolerance. Cytokines are central to these processes. These ...

In healthy people, binding of the molecule acetylcholine (ACh) to its receptor (AChR) on skeletal muscle cells triggers muscle contraction underlying regular daily activities. In the autoimmune ...

Immunothrombosis is increasingly recognized as a key pathophysiological process in emerging tropical diseases, linking innate immune responses, endothelial ...

Autoimmune diseases are a group of disorders that cause the immune system to mistakenly attack healthy cells, tissue or organs. This immune dysfunction can lead to inflammation, tissue damage and even ...

Nearly 1.5 million Americans and nearly 5% of women over the age of 55 have rheumatoid arthritis (RA), an incurable autoimmune disease marked by joint inflammation and subsequent damage. Despite ...