Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

United Kingdom doctors have reported eight healthy births via innovative DNA-enhanced IVF. This groundbreaking technique aims to prevent children from inheriting severe, incurable mitochondrial ...

The UK’s pioneering licensed IVF technique to reduce the risk of mitochondrial diseases carried out in Newcastle has seen eight babies born, published research shows. All eight babies show no signs of ...

A long-studied metabolic hormone, FGF21, also acts as a stress hormone—a discovery that helps explain how psychological stress causes metabolic dysregulation and drives physical disease, according to ...

More than half of people with mitochondrial disease can be diagnosed via genomic sequencing, a finding that will revolutionise care for families, according to a new study. And the Melbourne ...

Mitochondria are incredible organelles. They not only provide crucial power to our cells, but these little machines also have their own tiny little genomes, and can even make their own proteins. But ...

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory ...

Primary mitochondrial diseases caused by mutations in the nuclear and mitochondrial genome represent the largest group of inborn errors of metabolism with a prevalence of about 1 in 4,300. During the ...

Area of Focus: mitochondrial quality control, cellular metabolism, immune responses and the mechanisms underlying neurodegenerative diseases. Fourteen years ago, Xin Qi joined the Department of ...

As of 2019, about 4.9 million people globally were living with an inflammatory bowel disease (IBD) such as Crohn’s disease. Scientists are still unclear as to the exact cause of Crohn’s disease, which ...