Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

Management of mitochondrial-related heart disease relies on multidisciplinary care and symptom control, as targeted gene-editing therapies are limited.

Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear ...

Mitochondria are essential organelles that drive energy production, regulate apoptosis and orchestrate metabolic signalling within cells. Their dynamic nature underpins processes as diverse as ATP ...

Inhibition of mitochondrial RNA polymerase (POLRMT) drives significant weight loss and improved metabolic markers in obese mouse models. Findings underscore the promise of targeting mitochondrial ...

Understanding the mechanisms governing transcription of the mammalian mitochondrial DNA genome may offer the possibility of novel treatments for human diseases of mitochondrial dysfunction. In an ...

Aging, neurological diseases and our bodies’ stress response are all linked to the tiny power plants inside each cell known as mitochondria. To function properly, mitochondria must first read ...

In a study published in the journal Nature Metabolism, researchers treated male mice on a high-fat diet (HFD) with an inhibitor of mitochondrial transcription (IMT). They found that this shifted the ...

T cell mitochondria transcription factor A or TFAM is a DNA protein essential for the mitochondrial’s separate unique genome sequence and maintenance. When it is genetically modified (TFAM deficiency) ...

Researchers at the Karolinska Institute may have found a new way to treat obesity and related disorders by targeting the mitochondria. Their findings in mice demonstrate that a specific class of drugs ...