A phylogenetic tree of SARS-CoV-2 sequences, built with Nextstrain, displays sequences colored by their clade and organized by collection date. Over time, sequences mutate and diverge, forming new ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain cancers. In order to study these mutations, scientists need to introduce ...

The ability of mutations to cause cancer depends on how fast they force cells to divide, Sinai Health researchers have found. The research findings, published in Nature, have implications for ...

It's been five years since COVID-19 was declared a global pandemic. As SARS-CoV-2 shifts to endemic status, questions about its future evolution remain. New variants of the virus will likely emerge, ...

Researchers have found that a genetic mutation associated with a rare group of blood cancers does not always result in ...

Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of ...

HER2-mutated non-small-cell lung cancer (NSCLC) is a rare form of lung cancer where the cancer cells have a mutation that makes them grow and divide in an uncontrolled way. You can best understand ...

Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production. "We know that many diseases—and all cancers ...

Using the gene scissors CRISPR and stem cells, researchers at Stockholm University and the UK Dementia Research Institute (UK DRI) at King’s College London have managed to identify a common ...

GATA2 germline mutations lead to a syndrome characterized by immunodeficiency, vascular disorders and myeloid malignancies. To elucidate how these mutations affect hematopoietic homeostasis, we ...