A novel mechanism based on targeting MARK2 to destabilize mutant p53 (mutp53) and suppress triple-negative breast cancer (TNBC) progression, ...
The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long dubbed the protein p53 as the “guardian of the genome,” ...
In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...
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