The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future ...

What makes distinct species have different proteins? Is there a key that allows eukaryotic cells to produce proteins involved in multicellularity that are mostly absent in prokaryotes? What makes ...

Prokaryotic cells, which include all bacteria and archaea, are ancient, and relatively simple compared to eukaryotic cells, which are found in fungi, plants, and animals. Scientists have long sought ...

Bacteria and archaea use protein filament systems to organize cellular processes in time and space. Filaments can act as static scaffolds or as dynamic motors. In some cases, these filament systems ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms. The ...

Since the bacterial-origin CRISPR-Cas system rose to popularity as a genome editing tool, scientists have wondered whether other genome editors exist in nature. Now, two independent research teams ...

Enzymes have clearly defined active sites to allow the substrate molecule to fit intricately. This is often coupled with an enzymatic conformational change prior to the occurrence of the catalysis ...