Accurate DNA replication is essential for genome maintenance. Two recent reports have uncovered new molecular mechanisms controlling the termination phase of DNA replication in higher eukaryotes and ...

A series of electron micrographs show the barrel-shaped helicase with several components of the replisome: a) helicase (grey) with Ctf4 (light blue), which is a recruitment factor for the ...

Until now, the exact configuration of the replisome, a protein complex that unzips and copies DNA, has been unknown. After taking the first pictures of this complex, researchers were surprised to find ...

Scientists look at the base pairs that compose the "rungs" of the DNA ladder to determine a genome's sequence. The success of E. coli bacteria depends on their ability to multiply very rapidly by ...

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome--a block of proteins responsible for unwinding the DNA ...