Molecular simulations and network analysis revealed an interaction that explained an base-identity preference found in ...

The locking arm trigger in the glycine T-box riboswitch is part of another molecule called transfer RNA (tRNA). There are many types of tRNA in cells, but each acts like a kind of car, shuttling ...

A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription. When ...

Discover the latest articles and news in related subjects. To further validate cotranscriptional SHAPE-seq, we repeated our analysis of the SRP RNA by using dimethyl sulfate (DMS), an RNA-structure ...

(Phys.org)—A team of researchers working for pharmaceutical company Merck has found an instance of a molecule that is able to flip a switch in a bacterium that prevents it from synthesizing a needed ...

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics. A promising target for new and improved ...

Although one might think it would be simple, the genetics of bacteria can be rather complicated. A bacterium’s genes use a set of regulatory proteins and other molecules to monitor and change genetic ...

The Okinawa Institute of Science and Technology (OIST), in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of ...

In work with implications for functional studies and drug discovery, researchers have identified aptamer ligands (short folded RNAs) capable of distinguishing between on and off states of messenger ...

“Finding an antibiotic with a new target . . . has always been one of the holy grails of antibiotics discovery,” said RNA biochemist Thomas Hermann of the University of California, San Diego, who was ...

The last time I spoke about MeiraGTx Holdings plc (MGTX), it was in a Seeking Alpha article entitled "MeiraGTx: 2 Possible Near-Term BLA Filings Could Ignite Shareholder Value." With respect to this ...

In a discovery that points to potential new antibiotic medicines, scientists have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production. In a ...