Announcing a new publication for Acta Materia Medica journal. The binding affinity of aptamers to targets has a crucial role in the pharmaceutical and biosensing effects. Despite diverse ...

Each round of SELEX starts with a library of single-stranded ... granted in Japan and pending elsewhere) to the end of the aptamer, in order to improve tolerability to enzymatic degradation ...

Despite diverse post-systematic evolution of ligands by exponential enrichment (post-SELEX) modifications explored in aptamer optimization, accurate prediction of high-affinity modification strategies ...

The aptamer exhibiting high affinity for AFB1 was identified through a process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). This method began with the preparation of ...

For example, the FDA-approved aptamer drug Pegaptanib (Macugen) targets vascular endothelial growth factor (VEGF) for the treatment of age-related macular degeneration. Aptamers can be conjugated to ...