We show that the Rad50 hook domain is a critical determinant of this function by enabling the dimerization of chromatin-associated monomeric Mre11 complexes.

The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 ...

The problem of minimizing a concave function subject to linear inequality constraints may have many local solutions. Therefore, finding the global constrained minimum is a computationally difficult ...