Contact Information Subodh Verma, M.D., Ph.D., FRCSC, FAHA, FCAHS Toronto, CanadaProfessional Information ProfessorUniversity of Toronto ...

Whether a person eats a cookie or devours the whole box could come down to the mood of microglia in their hypothalamus. Blocking activation of the region’s NLRP3 inflammasome could keep excessive ...

The APOE4 allele heightens the risk of Alzheimer’s disease in several ways. Here’s a new one: It may deprive neurons of a crucial fuel. In the October 16 Nature Metabolism, scientists led by Thomas ...

For people with cerebral amyloid angiopathy (CAA), the heightened risk of ARIA, i.e., inflammation around blood vessels, may outweigh any potential gains of anti-amyloid immunotherapy. But with about ...

Could stem cells step in to replace lost neurons in Parkinson’s disease? In three Phase 1 clinical trials, scientists tested lab-grown dopaminergic cells in small cohorts to assess safety and look for ...

Low-intensity transcranial focused ultrasound is a noninvasive, targeted neuromodulation technology. It uses mid- or low-frequency sound waves delivered from arrays applied to the outside of the head ...

In the Alzheimer’s brain, microglia diversify into several activation states. What controls this specialization? In a preprint posted to bioRxiv on October 13, scientists led by Martin Kampmann at the ...

To mark the 20th anniversary of Alzforum's launch in 1996, we have compiled a timeline reflecting the evolution of Alzheimer’s disease research, starting from Alois Alzheimer's public presentation of ...

APOE4 was originally studied in the context of blood lipids and cardiovascular disease and first characterized at the protein level as one of three inherited ApoE isoforms with unique ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

The APOE Christchurch variant was identified as a candidate protective factor against Alzheimer’s disease in a carrier of the PSEN1 “Paisa” mutation—the most common cause of familial autosomal ...

Feel like your head is spinning? Like a little blood sample in a centrifuge, perhaps? No need to panic. It just means you are straining, like the rest of us, to keep up with the Alzheimer's disease ...