Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

Recent epigenetics research has demonstrated that chromatin conformation plays an important role in various aspects of gene regulation. Chromosome Conformation Capture (3C) technology makes it ...

At the same time, this is a new approach to the study of chromatin structure, where polymer physics has historically reigned supreme." The implications of the research are two-fold.

Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear abnormalities to hotspots of aberrant chromatin regulation, potentially ...

The three-dimensional (3D) chromatin structure of Epstein–Barr virus (EBV) within host cells and the underlying mechanisms of chromatin interaction and gene regulation, particularly those involving ...

Instead, chromatin—a combination of DNA and proteins—forms a carefully organized 3D structure that plays a vital role in regulating biological processes.

“We are finding the 3D structure of the genome,” said Satoshi Namekawa, PhD, professor of microbiology and molecular genetics at the University of California, Davis, and senior author of one ...

As for chromatin 3D structure, BMI1s have been reported to maintain the compartment domains (CDs) generally, but the mechanism by which they function remains elusive.

A novel, freely available AI tool has cut the time it takes to determine chromatin structure from days to minutes. The 3D structure of DNA is important for controlling cell-specific gene expression ...

This method can be used on large populations of cells to calculate an average structure for a section of chromatin, or on single cells to determine structures within that specific cell. However, Hi-C ...

This method can be used on large populations of cells to calculate an average structure for a section of chromatin, or on single cells to determine structures within that specific cell.