Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

Overcoming tumor resistance to chemotherapy drugs has long been a challenge for oncology clinicians and researchers. Now, a new study suggests that blocking a key protein, p300, may force damaged ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

Researchers at the School of Biological Sciences of The University of Hong Kong (HKU) have uncovered how eukaryotic cells can ...

Researchers developed a DNA-scaffolded vaccine that achieves the first step in generating a significant population of B cells that produce broadly neutralizing antibodies against HIV.

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

DNA nanopyramids slip through the brain's protective barrier and release cancer drugs only when they detect the acidic ...

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...

A Singapore study led by Duke‑NUS Medical School and NUHS found that age, smoking, oral bacteria and genetic mutations ...