Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

In this webinar, learn how scientists use advanced human brain models to uncover treatment strategies for complex ...

Today, genomics is saving countless lives and even entire species, thanks in large part to a commitment to collaborative and ...

These discoveries could have important medical implications, including diagnostic tests for causes of infertility linked to genome folding.

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

3D genome structure guides sperm development Knowing how the genome folds to turn genes on and off could improve our understanding of fertility and developmental disorders Peer-Reviewed Publication ...

Genome 3D organization may have multiple distinct roles in transcriptional regulation, with some interactions acting as barriers, while others might “prime” or “poise” inactive genes for activation ...

Here we asked if G4 structures might directly alter 3D chromatin, and affect long-range interactions including the epigenetic state of chromatin. To address this, we inserted an array of G4s into an ...

Scientists have sequenced the largest known animal genome — and it's 30 times bigger than the human genome. The genome belongs to the South American lungfish (Lepidosiren paradoxa), a primeval ...

With a skin sample from a 52,000-year-old woolly mammoth, scientists are gaining new insights into what made the animals tick. The findings could also help controversial de-extinction efforts.

Scientists have assembled the most complete woolly mammoth genome in 3D, thanks to an incredible “freeze-dried” specimen. With its DNA preserved in a glass-like state, chromosomes were found ...