The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

Senescent cells, which are damaged and inflammatory, contribute significantly to aging. Researchers at the Max Planck ...

In mammals, mitochondrial Prx3 is equivalent to Prx1 in yeast ... since the proteasome also plays a role in gene transcription regulation, or if the protein oxidizes more. It may hyperoxidize and, as ...

Researchers have induced a senescent-like state in worms, providing a model to explore how senescence can be triggered and ...

A study by the Center for Redox Processes in Biomedicine ( Redoxoma ) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil ...

Researchers from the Chinese Academy of Sciences and Capital Medical University performed an integrated multi-omics study to ...

Combining omega-3 supplementation with resistance training significantly improved lipid profiles, inflammation markers, ...

Specifically, the authors find that ZMAT3 negatively regulates HKDC1, a gene involved in the control of mitochondrial respiration and cell proliferation. Strengths: Mechanistically, ZMAT3 suppresses ...

The mitochondrial genome is the full genetic complement of a mitochondrion. Mitochondrial DNA is only a small portion of the total DNA of a eukaryotic cell and in most species is solely inherited ...