Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set ...

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

A study by the Center for Redox Processes in Biomedicine ( Redoxoma ) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Mitochondrial deoxyribonucleic acid (mtDNA) plays a crucial role in energy production and abnormalities in mtDNA are linked to various diseases. However, its regulatory mechanism remains ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

Neuronal excitation triggers an influx of calcium into mitochondria, triggering transcription of mtDNA. Expression of oxidative phosphorylation components climbs, ramping up ATP. This coupling falters ...

To address this, Wenwen Li and colleagues investigated the role of mitochondrial transcription in cognition in the hippocampus of young and aged mice. Li et al. identified a novel coupling mechanism, ...

Recently we developed novel, first-in-class inhibitors of mitochondrial transcription (IMTs) (14). IMT treatment specifically targets mitochondrial RNA polymerase (POLRMT) and reduce transcription of ...

Figure 1. SUCLG1 controls POLRMT activity, mitochondrial gene transcription, and mitochondrial biogenesis in FLT3-mutant leukemia. Succinylation is a post-translational modification that attaches a ...