Announcing a new publication for Acta Materia Medica journal. The binding affinity of aptamers to targets has a crucial role in the pharmaceutical and biosensing effects. Despite diverse ...

Each round of SELEX starts with a library of single-stranded ... granted in Japan and pending elsewhere) to the end of the aptamer, in order to improve tolerability to enzymatic degradation ...

The aptamer exhibiting high affinity for AFB1 was identified through a process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). This method began with the preparation of ...

For example, the FDA-approved aptamer drug Pegaptanib (Macugen) targets vascular endothelial growth factor (VEGF) for the treatment of age-related macular degeneration. Aptamers can be conjugated to ...