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In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...
Such 3D changes of the DNA are in turn controlled by other sequences called topologically associating domains ... Inside every TAD there exist genes as well as the elements that regulate them, ...
This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.
In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to ...
Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, ... One key discovery was that TAD boundaries became more insulated after UV exposure.
Because DNA is twisted and coiled in a 3D shape, these promoters can control genes that are located far away from them in the DNA's sequence. ... (TAD). Because of this complex mechanism, ...
A recent study published in the Journal of Medical Virology reviewed the current progress on three-dimensional (3D) interactions between host and viral genomes. Deoxyribonucleic acid (DNA), the ...
Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.
Scientists have assembled the most complete woolly mammoth genome in 3D, thanks to an incredible “freeze-dried” specimen. With its DNA preserved in a glass-like state, chromosomes were found ...
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