San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The 49ers (5-7) are alone in last place in the NFC West for the first time since the 2020 season ended. On the heels of this ...

McCaffrey slid down untouched in the backfield after taking a toss, then immediately went to the 49ers’ medical tent and ...