BMJ

Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE)

1 King’s College London Faculty of Life Sciences and Medicine, London, UK Introduction Crohn’s disease (CD) is a chronic, immune-mediated inflammatory bowel disease (IBD), presenting with symptoms of ...
IEEE

Protocol-Based Reliable Control for 2-D Fuzzy Systems Subject to Fading Networks

Abstract: This paper investigates the fuzzy censoring control problem for two-dimensional (2-D) discrete fuzzy systems characterized by the Roesser model. A novel event-triggered random protocol based ...
C&EN

Exploring the Effectiveness of Three-Dimensional Molecular Representations in Caco-2 Permeability Prediction

Caco-2 monolayer assays are widely used to assess drug absorption, yet existing predictive approaches mainly rely on predefined features and 2D representations, potentially overlooking key 3D ...
Frontiers

Sustainable innovation with a method based on peripheral mononuclear cells to screen, monitor and stratify the population at risk of osteoporosis and fractures – a ...

Introduction: Osteoporosis (OP) is a growing global public health challenge, often underdiagnosed and underestimated due to limitations in current diagnostic tools such as DXA-based bone mineral ...
C&EN

Challenges of Aufheben to Promote Druglikeness: Chemical Modification Strategies to Improve Aqueous Solubility and Permeability

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan ...
Medical Xpress

Gene linked to beta cell identity loss may explain type 2 diabetes progression

Scientists at City of Hope have uncovered a gene called SMOC1 that plays a surprising role in the development of type 2 diabetes (T2D) by converting pancreatic cells that normally produce insulin into ...