A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

A study by the Center for Redox Processes in Biomedicine ( Redoxoma ) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Researchers have now uncovered the role of mitochondrial transcription elongation factor in maintaining the balance between mtDNA transcription and replication. These findings provide valuable ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial ...

Using live two-photon imaging of a mitochondrial calcium sensor, Li and colleagues found that, sure enough, calcium flooded the mitochondria of neurons in the somatosensory cortex that were excited by ...

To address this, Wenwen Li and colleagues investigated the role of mitochondrial transcription in cognition in the hippocampus of young and aged mice. Li et al. identified a novel coupling mechanism, ...

Mitochondria are key cellular organelles that control energy production, stress response, and cell fate. Mitochondrial fitness is paramount to cellular homeostasis and organismal health, and its ...

They showed that mitochondria in the sperm's precursor cells did contain DNA, along with an important protein called mitochondrial transcription factor A (TFAM) that maintains and protects that DNA.

Researchers found that sperm cells are not only devoid of intact mtDNA, but they also lacked a protein essential for mtDNA maintenance, known as mitochondrial transcription factor A, or TFAM.