Learn more about the research of Mayo Clinic's Gene Editing and Cellular Engineering Laboratory led by David (Chun-Wei) D.

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to ...

When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.

Scientists have for the first time sequenced the most complete and oldest ancient Egyptian genome ever found—unlocking new ...

The 3D structure of the genome is assembled through chromatin folding and the spatial organisation of large chromatin domains, creating distinct regulatory compartments for processes like ...

Specifically, TAD boundaries are more likely to occur in regions of lower DNA-packing density, where the chromatin adopts 3D configurations with increased spatial expansion. This expansion promotes ...

Topologically associating domains (TADs) are fundamental 3D genome structures that facilitate key gene regulatory interactions. The boundaries of TADs are rich in functional elements critical for ...

Abstract The 3D genome prediction in cancer is crucial for uncovering the impact of structural variations (SVs) on tumorigenesis, especially when they are present in noncoding regions. We present ...