In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Such 3D changes of the DNA are in turn controlled by other sequences called topologically associating domains ... Inside every TAD there exist genes as well as the elements that regulate them, ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.

EPFL scientists show how DNA is organized into specific regions, ... (TAD, thick green line). ... Such 3D changes of the DNA are in turn controlled by other sequences called topologically ...

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, ... One key discovery was that TAD boundaries became more insulated after UV exposure.

Class of neurological disorders share 3D genome folding pattern Date: September 18, 2018 Source: University of Pennsylvania Summary: Researchers have found a new common thread linking nearly all ...

A recent study published in the Journal of Medical Virology reviewed the current progress on three-dimensional (3D) interactions between host and viral genomes. Deoxyribonucleic acid (DNA), the ...

Because DNA is twisted and coiled in a 3D shape, these promoters can control genes that are located far away from them in the DNA's sequence. ... (TAD). Because of this complex mechanism, ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.