Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

In the San Francisco 49ers' most recent primetime appearance, All-Pro tight end George Kittle made history on two fronts in ...

The San Francisco 49ers and Buffalo Bills are set to face-off in the Week 13 edition of Sunday Night Football. Before the season began, this matchup was circled ...

Related: Bills Can Make History vs. 49ers on 'SNF' "Lots of things can happen between now and then, but right now he's ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five ...

Three things I’m pondering as the Bills return from their bye for the stretch run… Mila-No More Waiting Matt Milano is ...

Brock Purdy revealed what he thought about while standing on the sideline at the of the San Francisco 49ers' loss to the ...

The former All-Pro has been out since the Bills faced the Jaguars in London last season and his return is a huge boost for ...

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.