Cartoon ICE agents raid Ball Arena in Denver during a Dora the Explorer Live! performance and arrest many of the attendees, seniors and children among them.

In the episode, South Park Elementary guidance counselor Mr. Mackey gets fired due to the government "cutting back on unnecessary expenses" — a reference to the Trump administration and the Department of Government Efficiency's (DOGE) extensive cuts across the government.

Homeland Security Secretary Kristi Noem received the South Park treatment Wednesday night, in an episode featuring the secretary as a dog-killing, botox-receiving law enforcement officer. South Park’s second episode of season 27 focused on Mr.