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5:54
YouTube
Coag Coach
G6PD Deficiency
In red blood cells, G6PD (glucose-6-phosphate-dehydrogenase) is important for the formation of NADPH (Nicotinamide adenine dinucleotide phosphate), which helps relieve oxidative stress through the action of glutathione. Therefore, G6PD deficiency leads to red blood cell intolerance of oxidative stress and immune (DAT-negative) hemolytic anemia.
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G6PD deficiency References: Richardson SR, O'Malley GF. Glucose 6 Phosphate Dehydrogenase Deficiency. [Updated 2022 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470315/ Pankey AN, Chandar A, Isaacson G. Safety of Ibuprofen in Children With G6PD Deficiency: A Systematic Review. Laryngoscope. 2022 Jun;132(6):1300-1305. doi: 10.1002/lary.29868. Epub 2021 Sep 21. PMID: 34546579. | Dr. Kilimanguru
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